Saturday, 30 April 2011

Mutations in single gene may have shaped human cerebral cortex

In my chapter BRAIN-BUILDERS in NOT A CHIMP I discuss the research, and criticism of that research, that suggests that several genes closely involved in cell division, are inordinately responsible for the great growth, relative to other primates, of the human cerebral cortex. here is a report of a third gene that seems to have a strong effect in the same area. From an analysis of Turkish and Pakistani families with a history of very severe truncation in brain development, a gene NDE1 was found to be implicated. This is involved in the behaviour of the centrasome - where chromosomes line up to reassemble after cell division in the nucleus.

Code rage: The "warrior gene" makes me mad! (Whether I have it or not)

Here's a nice "pissed off" piece in Scientific American by John Horgan, on the total and cynical over-hyping of the discovery of weak links between a low DNA repeat allele of monoamine oxidase (MAO-L) - an enzyme involved in the metabolism of both serotonin and dopamine - and rage and violence.