Thursday, 23 February 2012

Our Missing Genes

In a chapter titled LESS IS MORE in my book NOT A CHIMP I talk about a number of loss-of-function mutations in the human genome where a gene that functions in our primate cousins has become silenced in us. Turned into a pseudogene. Sometimes this can lead to disease and sometimes it can be shown that it is adaptive - part of the evolution of our genome. In this report on a recent SCIENCE paper, the research group found over 1000 genuine loss-of-function mutations in the human genome and suggested every European has at least 20 of them.

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