Monday, 6 July 2009

Beyond The Book Of Life

Interesting article from NEWSWEEK about epigenetics. Unlike genetic changes that work by mutations which alter letters in the genetic code of genes, and unlike other forms of gene regulation where promoter sequences upstream of genes regulate their activity, epigenetics focuses on the regulation of genes by chemicals which screen DNA from being read and implemented or bind it so tightly that it cannot be transcribed. DNA methylation, and histone attachment would be two prime examples. In this way gene-environment interactions, resulting in such epigenetic regulation of genes, may be passed down the generations. So, for instance, heavy smokers might pass on lasting epigenetic changes, relevant to the disease process, to their children. How much might epigenetics contribute to differences between primate species - particularly chimps and humans?

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